Associate Professor of Biomedical Sciences
道奇厅423号
(248) 370-2399
(电子邮件保护)
传记
Dr. Dao-Qi张 received his Ph.D. in neurobiology from the Institute of Physiology, Chinese Academy of Sciences in 1997. He completed his post-doctoral training within the Department of Physiology at the University of Kentucky. Before he joined 韦德体育app官网, Dr. Zhang served as 研究 Assistant Professor in the Department of Biological Sciences at V和erbilt University. Dr. Zhang was a tenure-track Assistant Professor from 2010 to 2017 at the 眼科研究所. Since 2017, he has been promoted to Associate Professor with tenure. Dr. Zhang has been also appointed as Adjunct Associate Professor at the Functional Medical Studies in 韦德体育app官网 William Beaumont School of 医学 since 2022.
研究
Dopamine is a key neurotransmitter that can influence cognition, emotion, movement in the 中枢神经系统. 在视觉系统中, dopamine plays a vital role in modulating retinal circuits, synchronizing the retinal clock, 影响眼睛生长. 结果是, dopamine deficiency leads to defects in the spatial 和 temporal vision in diabetic retinopathy, 早产儿视网膜病变, 帕金森氏症. Dopamine deficiency is also associated with the development of myopia, a common cause of visual disability throughout the world. The sole source of retinal dopamine is a specialized subtype of amacrine interneurons called dopaminergic amacrine cells. 博士的广泛目标. Zhang’s laboratory is to determine how dopamine release from dopaminergic amacrine cells is regulated before 和 after visual experience 和 how the regulation of the dopamine release is altered during eye disorders. 具体地说, they determine how spontaneous retinal activity occurring prior to eye opening, 称为"视网膜波", drives dopaminergic amacrine cells, 影响眼部生长. They also define the cellular 和 molecular mechanisms by which outer retinal photoreceptors (rods 和 cones) 和 inner retinal photoreceptors (melanopsin-expressing retinal ganglion cells) each excite dopaminergic amacrine cells contributing to visual information processing. 此外, they access the impairment of visual signaling pathways following oxygen-induced retinopathy, the most widely used model for 早产儿视网膜病变 和 human ischemic retinopathies, its impact on the development of myopia. The broader impact of the work will enable the rational discovery of new preventive, therapeutic interventions to combat eye disorders. Additional information is available on the Zhang Laboratory 网页.
资金
国家眼科研究所
中西部Eyebanks
研究 Excellence Fund (韦德体育app官网)
选定的出版物
燕R.-S，杨X.-L.，钟锐.-M*. 和 张D.-Q.* (2020) Spontaneous depolarization-induced action potentials of ON-starburst amacrine cells during cholinergic 和 glutamatergic retinal Waves. 细胞, 9(12):2574. (*共同通讯作者).
刘L.-L，斯皮克斯N.J. 和 张D.-Q . (2017) NMDA receptors contribute to retrograde synaptic transmission from ganglion cell photoreceptors to dopaminergic amacrine cells. Frontier in Cellular Neuroscience 11:279 (1-13).
乔年代.-N.周伟.，刘丽.-L. 张D.-Q. * 和钟宇.-M.* (2017) Orexin-A suppresses signal transmission to dopaminergic amacrine cells from outer 和 inner retinal photoreceptors. 调查眼科 & 视觉科学 58(11):4712-4721 (*共同通讯作者).
赵X.黄健.Y. 和 张D.-Q. (2017) Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina. 科学报告 7:7920 (1-14).
Prigge C.L.，叶P.T.刘宁.F.、李C.C.， You S.F.，刘丽.-L.，麦克尼尔D。.S, Chew K.S.哈塔·S.，陈思.K.*和 张D.-Q .* (2016) M1 ipRGCs influence visual function through retrograde signaling in the retina. 神经科学杂志 36:7184-97. (*共同通讯作者).
乔年代.-N.，张志，Ribelayga C.P.，钟毅.-M.*和 张D.-Q.* (2016) Multiple cone pathways are involved in photic regulation of retinal dopamine. 科学报告 6:28916 (1-13). (*共同通讯作者).
Spix N.J.，刘丽.-L.，张志，霍尔拜因J.P.C.Z.， Chintala S, Ribelayga C.P., 张D.-Q . (2016) Vulnerability of dopaminergic amacrine cells to chronic ischemia in a mouse model of oxygen-induced retinopathy. 调查眼科 & 视觉科学 57:3047-57.
张D.-Q ., 黄K.Y.伯森·D.M.索勒斯P.J.皮卡德·G.E. D.G. (2008) Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons. Proceedings of the National Academy of Science, USA 105:14181-14186.
张D.-Q.、周涛.-R. D.G. (2007) Functional heterogeneity of retinal dopaminergic neurons underlying their multiple roles in vision. 神经科学杂志 27:692-699.
张D.-Q. D.G. (2000) Direct gating by retinoic acid of retinal electrical synapses. Proceedings of the National Academy of Science, USA 97:14754-14759.
研究
Dopamine is a key neurotransmitter that can influence cognition, emotion, movement in the 中枢神经系统. 在视觉系统中, dopamine plays a vital role in modulating retinal circuits, synchronizing the retinal clock, 影响眼睛生长. 结果是, dopamine deficiency leads to defects in the spatial 和 temporal vision in diabetic retinopathy, 早产儿视网膜病变, 帕金森氏症. Dopamine deficiency is also associated with the development of myopia, a common cause of visual disability throughout the world. The sole source of retinal dopamine is a specialized subtype of amacrine interneurons called dopaminergic amacrine cells. 博士的广泛目标. Zhang’s laboratory is to determine how dopamine release from dopaminergic amacrine cells is regulated before 和 after visual experience 和 how the regulation of the dopamine release is altered during eye disorders. 具体地说, they determine how spontaneous retinal activity occurring prior to eye opening, 称为"视网膜波", drives dopaminergic amacrine cells, 影响眼部生长. They also define the cellular 和 molecular mechanisms by which outer retinal photoreceptors (rods 和 cones) 和 inner retinal photoreceptors (melanopsin-expressing retinal ganglion cells) each excite dopaminergic amacrine cells contributing to visual information processing. 此外, they access the impairment of visual signaling pathways following oxygen-induced retinopathy, the most widely used model for 早产儿视网膜病变 和 human ischemic retinopathies, its impact on the development of myopia. The broader impact of the work will enable the rational discovery of new preventive, therapeutic interventions to combat eye disorders. Additional information is available on the Zhang Laboratory 网页.
资金
国家眼科研究所
中西部Eyebanks
研究 Excellence Fund (韦德体育app官网)
选定的出版物
燕R.-S，杨X.-L.，钟锐.-M*. 和 张D.-Q.* (2020) Spontaneous depolarization-induced action potentials of ON-starburst amacrine cells during cholinergic 和 glutamatergic retinal Waves. 细胞, 9(12):2574. (*共同通讯作者).
刘L.-L，斯皮克斯N.J. 和 张D.-Q . (2017) NMDA receptors contribute to retrograde synaptic transmission from ganglion cell photoreceptors to dopaminergic amacrine cells. Frontier in Cellular Neuroscience 11:279 (1-13).
乔年代.-N.周伟.，刘丽.-L. 张D.-Q. * 和钟宇.-M.* (2017) Orexin-A suppresses signal transmission to dopaminergic amacrine cells from outer 和 inner retinal photoreceptors. 调查眼科 & 视觉科学 58(11):4712-4721 (*共同通讯作者).
赵X.黄健.Y. 和 张D.-Q. (2017) Mapping physiological inputs from multiple photoreceptor systems to dopaminergic amacrine cells in the mouse retina. 科学报告 7:7920 (1-14).
Prigge C.L.，叶P.T.刘宁.F.、李C.C.， You S.F.，刘丽.-L.，麦克尼尔D。.S, Chew K.S.哈塔·S.，陈思.K.*和 张D.-Q .* (2016) M1 ipRGCs influence visual function through retrograde signaling in the retina. 神经科学杂志 36:7184-97. (*共同通讯作者).
乔年代.-N.，张志，Ribelayga C.P.，钟毅.-M.*和 张D.-Q.* (2016) Multiple cone pathways are involved in photic regulation of retinal dopamine. 科学报告 6:28916 (1-13). (*共同通讯作者).
Spix N.J.，刘丽.-L.，张志，霍尔拜因J.P.C.Z.， Chintala S, Ribelayga C.P., 张D.-Q . (2016) Vulnerability of dopaminergic amacrine cells to chronic ischemia in a mouse model of oxygen-induced retinopathy. 调查眼科 & 视觉科学 57:3047-57.
张D.-Q ., 黄K.Y.伯森·D.M.索勒斯P.J.皮卡德·G.E. D.G. (2008) Intraretinal signaling by ganglion cell photoreceptors to dopaminergic amacrine neurons. Proceedings of the National Academy of Science, USA 105:14181-14186.
张D.-Q.、周涛.-R. D.G. (2007) Functional heterogeneity of retinal dopaminergic neurons underlying their multiple roles in vision. 神经科学杂志 27:692-699.
张D.-Q. D.G. (2000) Direct gating by retinoic acid of retinal electrical synapses. Proceedings of the National Academy of Science, USA 97:14754-14759.